Microbar HD

Nervous system disorders

Microbar Products

There are Microbar Products offered by us that are high-quality micronized barite used as a weighting agent for nonaqueous drilling fluid applications. Compared with API drilling-grade barite, the MicroBar additive reduces barite sag and settlement. The Microbar powder is a unique formulation containing coarse particles of barium sulphate Most economical and ideal for routine examination of G.I tract. Microbar Paste is ideal for x-ray diagnosis of oesophagus and pharynx. It is a smooth pink colored mobile paste and contains coarse barium sulphate particles. The Microbar Products are offered by us in various types and are suitable for medical uses.

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Contact Details

• 3A/4, Commercial Block, Ram Apartments, 4th Lane, Pandurang Wadi, Goregaon (East), Mumbai – 400063, Maharashtra, India
• Phone : 08037405141
• Fax : 91-22-28747434

• Mr Rajesh Mohan Chikramane ( Managing Director )
• Mobile : 08037405141
• Ms. Jyoti D. Bijoor ( Director )
• Mobile : 08037405141
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• Additional Address : 1st Floor, D.R.Chambers, 12/56. D.B.Gupta Road, Karol Bagh, New Delhi – 110005
  Contact Person : Rajesh Bhatli (CEO)

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Microbar powder barium suspension azərbaycan

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Microbar HD
Qualitative and quantitative composition

The information provided in Qualitative and quantitative composition of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Qualitative and quantitative composition in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Barium Sulfate
Therapeutic indications

The information provided in Therapeutic indications of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

This medicinal product is for diagnostic use only.

Microbar HD is a high density suspension for use as a radiopaque agent during X-ray visualisation of the upper gastro-intestinal tract (oesophagus, stomach and duodenum). It is designed for optimal use in double contrast X-ray examinations.

Microbar HD is indicated in adults and children.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Microbar HD must be administered orally. The powder must be reconstituted prior to administration.

The administered dose of Microbar HD will depend on the patient in question and the section of the gastrointestinal tract to be viewed.

Method of Administration

Adults: The contents of one prefilled bottle (340 g) are dispersed in 65 mL of water to produce a 250 % w/v suspension which is swallowed by the patient after a suitable gas producing agent has been administered.

Children: The dosage will be dependent on the size, age, health state and anatomical region to be imaged of the child. Individual requirements should be determined, from experience, by the radiologist.

Elderly: There are no special dosage recommendations. The dosage should be determined, from experience, by the radiologist.

Contraindications

The information provided in Contraindications of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Immune System Disorders

Gastrointestinal Disorders

Patients with any of the following:

– a known or suspected, perforation of the gastrointestinal tract

– known or suspected trachea-esophageal fistula

– megacolon or toxic megacolon

should not receive Microbar HD.

Microbar HD should not be used for infants with swallowing disorders.

Surgical and Medical Procedures

Barium Sulphate should not be administered immediately after gastrointestinal surgery, including snare polypectomy or ‘hot’ colonic biopsy because of the potential for post-surgical or post-procedural leakage or the potential for gastrointestinal perforation. In case the patient has to undergo gastrointestinal surgery immediately after barium sulfate administration, caution should be exercised.

Injury, Poisoning and Procedural Complications

Barium Sulphate products should not be used during and up to four weeks after radiotherapy to the rectum or prostate; similarly, Barium Sulphate products should not be used in patients with new injuries or chemical burns of the gastrointestinal tract.

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

The product should be administered under the supervision of a physician.

Diagnostic procedures which involve the use of radiopaque contrast agents should be carried out under the direction of personnel with the requisite training and with a thorough knowledge of the particular procedure to be performed.

Barium Sulphate should not be administered in its dry form. The powder must be reconstituted, and some of the commercially prepared suspensions require further dilution, prior to administration.

Hypersensitivity

A history of bronchial asthma, atopy, as evidenced by hay fever and eczema, a family history of allergy, or a previous reaction to a contrast agent warrant special attention. These responses are thought to be caused by the flavours and/or preservatives used in the product.

/or patient hypersensitivities. Anaphylactic and allergic reactions have been reported during double contrast examinations in which glucagon has been used. Rapid recognition, assessment, and diagnosis are crucial to the effective implementation of treatment. Imaging facilities should be staffed with well-trained personnel for the diagnosis and treatment of hypersensitivity reactions.

Barium sulfate preparations used as radiopaque media contain a number of additives to provide diagnostic properties and patient palatability. Allergic responses following the use of barium sulfate suspensions have been reported. Skin irritation, redness, inflammation and hives have been reported for infants and small children following spillage of barium sulfate suspension on their skin.

Perforation

In patients with a serious stenosis at any level of the gastro-intestinal tract, especially if it is distal to the stomach, and in the presence of conditions and ailments that increase the risk of perforation such as known gastrointestinal fistulae and carcinomas, inflammatory intestinal disease, diverticulitis and diverticulosis and amoebiasis, careful consideration of the risks and benefits of the administration of a barium sulfate suspension is required.

For patients who are prone to aspiration (the newborn, elderly and stroke patients), it is recommended that the procedure starts with a small ingested volume.

Vomiting following oral administration of barium sulfate may lead to aspiration pneumonitis. Oral administration of barium sulfate suspension by an infant sucking a bottle and administration of large quantities by catheter are reported to be likely to result in aspiration into the tracheobronchial tree. Cardiopulmonary arrest leading to fatality has been reported in infants following aspiration. Aspiration of smaller amounts may cause respiratory tract inflammation and pneumonia.

Ingestion of barium is not recommended in patients with a history of food aspiration. If barium procedures are required in these patients or in patients in whom integrity of the swallowing mechanism may be compromised, proceed with caution. If this product is aspirated into the larynx, further administration should be immediately discontinued.

Obstruction/Fluid Overload

Barium Sulphate suspensions, after oral administration, have been reported to cause obstruction of the small bowel (impaction) in paediatric patients with cystic fibrosis.

Barium sulfate suspensions have been reported to cause fluid overload due to water absorption.

Children and patients with impaired renal function are the most susceptible to water intoxication, as are children with Hirschsprung’s Disease.

Intravasation

Barium sulfate may also intravasate into the venous drainage of the large bowel and enter the circulation as a “barium embolus”. This complication occurs rarely during a barium enema and is exceedingly uncommon in oral administration. It can lead to potentially fatal complications, including systemic and pulmonary embolism, disseminated intravascular coagulation, septicaemia and prolonged severe hypotension. It is more likely to occur in elderly patients, due to thinning of the rectal wall and vaginal thinning with age, and in those with colorectal disease, when intraluminal pressure overcomes the resistance of the colonic wall affected by colitis, diverticulitis or intestinal obstruction. The diagnosis should be considered in any patient who collapses during or shortly after a barium procedure, and in those who become suddenly unwell in the hours following the procedure.

Constipation or Diarrhoea

Microbar HD should be used with care if the patient is dehydrated, suffers from any condition or is on any other treatment that can cause constipation, or if the patient has history of constipation. In this situation a mild bulk laxative should be administered following completion of the X-ray examination. Increased intake of liquids is recommended after oral or rectal administration of barium sulfate to prevent severe constipation and the risk of impaction.

Conversely, since Microbar HD contains sorbitol, administration may have a mild laxative effect. The calorific value of sorbitol is 2.6 kcal/g.

Other Possible Complications

Apprehensive patients may develop weakness, pallor, tinnitus, diaphoresis and bradycardia following the administration of any diagnostic agent. Such reactions are usually unpredictable and are best treated by having the patient lie flat for an additional 10 – 30 minutes under observation.

Patient preparation for diagnostic gastrointestinal examinations frequently requires cathartics and a liquid diet. The various preparations can result in water loss for the patient. Patients should be rehydrated quickly following a barium sulfate suspension examination of the gastrointestinal tract. Saline cathartics are recommended on a routine basis in patients with a history of constipation unless clinically contraindicated.

Baroliths consist of inspissated barium associated with faeces. They are often asymptomatic, but may be associated with abdominal pain, appendicitis, bowel obstruction, or perforation. Patients who are elderly, with impaired gastrointestinal motility, colon obstruction, electrolyte imbalance, dehydration or on a low residue diet may be at risk of developing baroliths. To reduce this risk, adequate hydration should be maintained during and in the days following barium sulfate procedure. The use of laxatives (especially in case of constipation) should be considered.

Hereditary Fructose Intolerance

Microbar HD contains sorbitol. Patients with rare hereditary problems of fructose intolerance should not use this medicine. Therefore, it should only be used in babies and small children after consultation with the doctor, due to the possibility of unknown hereditary fructose intolerance.

Patients on a Controlled Sodium Diet

Microbar HD contains sodium among the excipients. Care should be taken in patients on a controlled sodium diet, especially in the cases of repeated administration.

Children, Elderly and Debilitated Patients

As with any barium sulfate preparation, care should be taken when administering Microbar HD to children, the elderly or the debilitated. It should be used cautiously in patients with pre-existing heart disease.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Microbar HD has negligible influence on the ability to drive and use machines.

Undesirable effects

The information provided in Undesirable effects of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Undesirable effects may occur during or after a procedure with barium sulfate.

Skin and subcutaneous disorders together with immune system disorders, reflecting allergic reactions either to barium sulfate or the product excipients, are among the most commonly reported effects; for example urticaria, erythema and rash.

Gastrointestinal disorders are also one of the most frequently reported class of undesirable effects; for example diarrhoea, nausea, abdominal pain/distention, constipation.

Within the table below, clinically significant adverse reactions are listed if they have been reported during post approval use of all barium sulfate formulations. Their frequency is not known, therefore relative reporting rate (for example, less commonly) compared to overall reporting for barium sulfate is used.

MedDRA System Organ Class

Adverse events

Clinical Trails

Post-marketing Surveillance

Infections and infestations

Appendicitis, Bacteraemia. Less commonly other infections have been reported including rare cases of Abscess intestinal, Liver abscess, Peritoneal infection and Pneumonia

Blood and the lymphatic system disorders

Immune system disorders

Hypersensitivity presenting with a wide range of signs and symptoms including skin and subcutaneous reactions such as urticaria, pruritus, rash, erythema and facial swelling.

Potential hypersensitivity associated respiratory signs and symptoms including dyspnoea, pharyngeal oedema and throat tightness have been reported.

Anaphylactic reaction and anaphylactic shock have been reported less commonly.

Metabolism and nutrition disorders

Infrequent cases of Hyperglycaemia have been reported in diabetic patients

Agitation, Confusional state, Nervousness and related symptoms have been reported during the administration of barium sulfate

Nervous system disorders

Loss of consciousness, Syncope, Syncope vasovagal, Dizziness, Burning sensation, Headache, Dysarthria, Hypotonia

Eye disorders, including Eye swelling, usually associated with allergic reactions have been reported

Ear and labyrinth disorders

Bradycardia, Cyanosis, Tachycardia

Hypotension, Pallor, Vasodilatation

Respiratory, thoracic and mediastinal disorders

Bronchospasm, Dyspnoea, Laryngeal oedema, Pharyngeal oedema and pain, Throat irritation or tightness, Cough.

When administered orally, Aspiration, Pneumonia aspiration.

Abdominal pain Nausea; Vomiting

Gastrointestinal signs and symptoms are widely reported, it is not always possible to differentiate between pre-existing medical conditions and procedural complications. Events reported include:

Intestinal ischemia, Constipation and in severe cases gastrointestinal blockage; Gastrointestinal inflammation, ulceration or perforation; Abdominal discomfort, abdominaldistension; Diarrhoea; Colitis ulcerative may be aggravated; Retching; Flatulence; Swollen tongue

Skin and subcutaneous tissue disorders

Skin reactions are varied and most likely to be associated with allergic reactions.

Reports include: Erythema, Dermatitis Contact, Excessive granulation tissue, Hyperhidrosis, Periorbital oedema, Pruritus, Rash, Swelling face, Urticaria

Renal and urinary disorders

General disorders and administration site conditions

Malaise, Pain, Swelling, Asthenia, Pyrexia, Face oedema

Injury and poisoning

Intravasation by barium sulfate, associated with pre-existing bowel disease or diverticulitis, has been reported rarely, Barium impaction.

More rarely and depending on the route of administration, i.e. oral or rectal, the following procedural complications have been reported:

Infections (e.g. peritonitis) subsequent to existing or new gastrointestinal perforation. Complications include adhesions and granuloma.

Subsequent to existing or procedural gastrointestinal trauma, intravasation of barium sulfate with rare subsequent venous emboli formation, including the hepatic portal vein, vena cava and pulmonary embolism that may be fatal in approx 50% of cases.

Following oral administration, aspiration, with pulmonary complications, may occur and may be fatal in rare cases.

Very rare cases of death associated with barium sulfate administration have been reported in the literature. The majority of the deaths relate to procedural complications usually caused by failure to follow generally accepted radiological practice. Some cases had a history indicating that barium sulfate administration was highly unlikely to be a primary or even secondary causative factor in patient fatality.

The type of adverse reactions is similar in children and adults.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme – Website: www.mhra.gov.uk/yellowcard

The information provided in Overdose of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Barium sulfate is non-toxic and absorbed systemically in negligible amounts.

Repeated use within a very short period of time has led to abdominal cramps, nausea, vomiting, diarrhoea, and constipation. These symptoms are transitory in nature and may be allowed to resolve without medical intervention or may be treated according to currently accepted standards of care.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Pharmacotherapeutic group: X-ray contrast media, barium sulfate with suspending agents, ATC code: V08BA01

The active constituent of Microbar HD, barium sulfate, is inert and has no pharmacological action. It serves only as a radiopaque substance to opacify the gastro-intestinal tract during X-ray examinations.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Under physiological conditions, barium sulfate passes through the gastrointestinal tract in an unchanged form and is absorbed only in small, pharmacologically insignificant amounts.

Pharmacotherapeutic group

The information provided in Pharmacotherapeutic group of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Pharmacotherapeutic group in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

X-ray contrast media, barium sulfate with suspending agents, ATC code: V08BA01
Preclinical safety data

The information provided in Preclinical safety data of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

There are no preclinical data of relevance to the prescriber which are additional to that already included elsewhere in the SPC.

Incompatibilities

The information provided in Incompatibilities of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of Microbar HD is based on data of another medicine with exactly the same composition as the Microbar HD. . Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Microbar HD directly from the package or from the pharmacist at the pharmacy.

Reconstitution information for use of Microbar HD is provided below.

1. Add 65 mL of water to bottle.

2. Secure lid and invert bottle, tapping base to loosen powder.

3. Shake well for 10-20 secs. Leave until required.

4. Immediately before giving to patient to drink shake again for 10-20 secs.

Any unused, opened product or waste material should be disposed of in accordance with local requirements.

References:

• https://www.drugs.com/search.php?searchterm=microbar-hd
• https://pubmed.ncbi.nlm.nih.gov/?term=microbar-hd

Microbar Barium Sulphate Suspension, 1 Ltr

We are the wholesale suppliers of Barium sulphate and various medical products.. Contact us for more details.

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Product Specification

Packaging Size	1 Ltr
Brand	Microbar
Composition	Barium Sulphate Suspension
Country of Origin	Made in India
Used For	Hospitals,Laboratory,X ray,Scan
Delivery	1-2 Days
Minimum Order Quantity	1 Kg

Product Description

We are the wholesale suppliers of Barium sulphate and various medical products.. Contact us for more details.

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Year of Establishment 2014
Legal Status of Firm Individual – Proprietor
Nature of Business Wholesale Trader
Number of Employees Upto 10 People
Annual Turnover Rs. 50 Lakh – 1 Crore
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GST 37AEWPY3035K1ZM

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